| Date | Teams | Spread | Money | Total |
|---|---|---|---|---|
| Saturday, May. 04, 02:25 pm |
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| Milwaukee Brewers at | (+1.5) -178 | +118 | (O: 8.5) -110 | |
| Chicago Cubs | (-1.5) +158 | -128 | (U: 8.5) -110 | |
| Saturday, May. 04, 04:10 pm |
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| Colorado Rockies at | (+1.5) -121 | +190 | (O: 7) +105 | |
| Pittsburgh Pirates | (-1.5) +101 | -210 | (U: 7) -125 | |
| Saturday, May. 04, 06:10 pm |
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| San Francisco Giants at | (+1.5) -150 | +150 | (O: 7) -110 | |
| Philadelphia Phillies | (-1.5) +130 | -164 | (U: 7) -110 | |
| Saturday, May. 04, 08:15 pm |
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| San Diego Padres at | (+1.5) -183 | +111 | (O: 8.5) -115 | |
| Arizona Diamondbacks | (-1.5) +163 | -121 | (U: 8.5) -105 | |
| Saturday, May. 04, 09:15 pm |
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| Atlanta Braves at | (+1.5) -128 | +165 | (O: 8) -117 | |
| Los Angeles Dodgers | (-1.5) +108 | -180 | (U: 8) -103 | |
| Saturday, May. 04, 01:10 pm |
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| Detroit Tigers at | (+1.5) -150 | +148 | (O: 7.5) -114 | |
| New York Yankees | (-1.5) +130 | -162 | (U: 7.5) -106 | |
| Saturday, May. 04, 02:15 pm |
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| Boston Red Sox at | (+1.5) -140 | +157 | (O: 7.5) +104 | |
| Minnesota Twins | (-1.5) +120 | -172 | (U: 7.5) -124 | |
| Saturday, May. 04, 06:15 pm |
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| Los Angeles Angels at | (+1.5) -178 | +117 | (O: 8) -125 | |
| Cleveland Guardians | (-1.5) +158 | -127 | (U: 8) +105 | |
| Saturday, May. 04, 07:15 pm |
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| Texas Rangers at | (-1.5) 155 | -102 | (O: 8.5) -102 | |
| Kansas City Royals | (+1.5) -175 | -108 | (U: 8.5) -118 | |
| Saturday, May. 04, 07:20 pm |
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| Seattle Mariners at | (+1.5) -172 | +132 | (O: 7.5) +108 | |
| Houston Astros | (-1.5) +152 | -144 | (U: 7.5) -128 | |
| Saturday, May. 04, 02:20 pm |
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| Chicago White Sox at | (+1.5) -142 | +154 | (O: 8) -130 | |
| St. Louis Cardinals | (-1.5) +122 | -168 | (U: 8) +110 | |
| Saturday, May. 04, 04:10 pm |
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| Toronto Blue Jays at | (-1.5) 102 | -158 | (O: 8) +100 | |
| Washington Nationals | (+1.5) -122 | +145 | (U: 8) -120 | |
| Saturday, May. 04, 04:12 pm |
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| Miami Marlins at | (+1.5) -190 | +120 | (O: 7) +100 | |
| Oakland Athletics | (-1.5) +165 | -130 | (U: 7) -120 | |
| Saturday, May. 04, 06:45 pm |
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| Baltimore Orioles at | (-1.5) 154 | +101 | (O: 9) -105 | |
| Cincinnati Reds | (+1.5) -174 | -111 | (U: 9) -115 | |
| Saturday, May. 04, 07:20 pm |
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| New York Mets at | (+1.5) -215 | -105 | (O: 7.5) -108 | |
| Tampa Bay Rays | (-1.5) +185 | -105 | (U: 7.5) -112 |